NFL Odds Week 1: How to bet Browns-Panthers, choose

attacking player baker mayfield as much as browns fans have marked Sunday on their calendars as the carolina panthers Cleveland host.

Mayfield was the Browns’ No. 1 pick in 2018 and led them to their first playoff win since 1994 in 2020, but requested a trade this offseason after Cleveland traded Deshaun Watson. Watson is suspended for 11 games.

Here you will find everything you need from a betting perspective on the Browns-Panthers game, from the point spread, the money line, the total over/under and a selection of our NFL expert (odds via FOX Beth):

Will Baker Mayfield lead the Panthers to an NFC playoff spot? | INDISPUTABLE

Will Baker Mayfield lead the Panthers to an NFC playoff spot?  |  INDISPUTABLE

Skip Bayless answers if the Panthers will make the playoffs with Baker Mayfield under center.

RELATED: How Deshaun Watson’s suspension affected the odds

Cleveland Browns @ Carolina Panthers (1 p.m. ET, Sunday, CBS)

Point difference: Panthers -2.5 (Panthers favorite to win by 2.5+ points, otherwise Browns cover)
money line: Panthers -143 favorites to win (bet $10 to win $16.99 total); Browns +120 underdogs to win (bet $10 to win $22 total)
Total score over/under: 41.5 points scored by both teams combined

cleveland browns


carolina panthers


The Browns are looking to end a season-opening drought. Cleveland is 0-16-1 in its last 17 Week 1 games. The last time the Browns won their season opener was in the 2004 season; every other team has at least five wins in Week 1 since then.

The Browns covered the spread seven times in 17 games last year.

As underdogs of 2.5 points or more, the Browns went 3-3 last year against the spread (ATS).

The Browns had seven of their 17 games in the over/under (O/U) last season.

The Panthers finished 2021 with a 5-12 record after starting the season 3-0, becoming the first team in NFL history to lose 12 games in a season following a 3-0 start. The Panthers have lost seven straight games, the longest active losing streak in the NFL.

Mayfield will be Carolina’s fourth different Week 1 starting quarterback in as many seasons.

Carolina’s offense averaged 4.6 yards per play in 2021, the lowest in the NFL. The return of Christian McCaffrey should help with that.

The Panthers went 5-12 ATS last season.

FOX Sports NFL Writer’s Choice Eric Williams:

With Baker Mayfield facing his old team, the Oklahoma product will be duly motivated.

But I like that the Browns lean on their defense and running game here, with quarterback Jacoby Brissett making enough plays on the road for Cleveland to pull out a win.

Cleveland has won two of the last three matchups between these two teams. So in their first game without Deshaun Watson, I like the Browns to win outright.

TO CHOOSE: browns money line (+120 on FOX Bet, bet $10 to win $22 total) to win completely

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